Food, lifestyle and GLP-1

Eating, moving and living well when your appetite changes

Saciedad explains, clearly and with sources, what happens to appetite, food and daily habits on a GLP-1 medication such as semaglutide or tirzepatide, and without one. These English guides are adapted for US readers, with US drug names, FDA status and US food examples; they are general information written by a person, never a substitute for your doctor.

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Editorial principles

  • Primary sourcesDrug labels, regulators, trials and official databases, with the access date.
  • Checkable figuresEvery drug-label fact carries the date it was checked.
  • Scheduled reviewEvery article shows when it was last updated and when it is next due for review.
  • IndependentNo advertising from drug companies and no affiliate links.

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All English guides

What the trials show

Plain-English summaries of the most important clinical trials of GLP-1 medications, with their numbers, their limitations and a link to the original paper.

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  • STEP 1New England Journal of Medicine, 2021

    People with obesity or overweight, without diabetes · 68 weeks

    Semaglutide 2.4 mg weekly
    −14.9%
    Placebo
    −2.4%
  • SURMOUNT-1New England Journal of Medicine, 2022

    People with obesity or overweight, without diabetes · 72 weeks

    Tirzepatide 15 mg weekly
    −20.9%
    Placebo
    −3.1%

Mean weight loss, % of starting weight. Each trial is compared only with its own placebo.

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Foods, with the source of every figure

The food database has 219 foods with protein, fiber, calories and satiety per serving, in English.

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Most filling (estimated)USDA FoodData Central
FoodTypical servingProtein per servingkcal per servingEstimated satiety
Yellowfin tuna150 g (5.5 oz)36.6 g1645 of 5
Canned tuna in water60 g (2 oz)15.3 g705 of 5
Cod150 g (5.5 oz)26.7 g1235 of 5
Egg whites66 g (2.5 oz)7.2 g345 of 5
Tilapia150 g (5.5 oz)30.2 g1445 of 5

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